Synthesis of derivatives of sphingosine and development of an agonist for sphingosine 1-phosphate receptors

ORGN 167

Deok Seong Park, blue_sahara@naver.com1, Baeck Kyoung Lee1, Dong Sub Kim1, Won Koo Lee1, and Hyun-Joon Ha2. (1) Department of Chemistry and Interdisciplinary Program of Integrated Biotechnology, Sogang University, Ricci building unit1318 Sinsu #1 Mapo, Seoul, South Korea, (2) Department of Chemistry, Hankuk University of Foreign Studies, Yongin 449-791, Kyoung Gi Do, South Korea
Derivatives of sphingosine were designed and synthesized by addition of phosphate to terminal alcohol of sphingosine and functionalized aryl group The addition of sphingosine 1-phosphate leads to a change in the cell morphology of rat C6 glioma cells. In this study, we determined that DS-SG-44 is an agonist of S1P receptors by using this morphologic change as a response marker. Our results suggest that DS-SG-44, a newly-synthesized S1P analogue, acts as an S1P receptor agonist.

 

Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007