Combinatorial high throughput synthesis within continuous flow reactors

ORGN 12

Paul Watts, P.Watts@hull.ac.uk and Charlotte Wiles, c.wiles@chem.hull.ac.uk. Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, United Kingdom
Flow reactors offers many fundamental and practical advantages of relevance to the pharmaceutical industry; who are searching for controllable, information rich, high throughput, environmentally friendly methods of rapidly producing products with a high degree of chemical selectivity. In this presentation a number of chemical reactions will be used to illustrate the advantages that these reactors offer for the rapid optimisation of reactions, in which the products are produced in both higher yield and purity. Such methodology is ideal for process chemistry. It will be illustrated that compounds may be prepared and purified within an integrated system and that it is possible to generate intermediates in situ within the reactor, which may be subsequently reacted to produce more complex products.