ORGN 168 |
| Reactive oxygen species (ROS) such as superoxide and hydroxyl radicals are produced in excess during periods of oxidative stress. These radicals can react with biomolecules causing cell dysfunction or apoptosis. As a result ROS are linked to a number of diseases as well as the degenerative effects of ageing. Reactive oxygen species have a short lifetime and are difficult to detect, therefore a technique known as spin-trapping is employed for the investigation of ROS. Utilising a new route to a dihydroisoindole motif a novel spin-trap has been synthesised. The spin trap is targeted to mitocondria the main source of ROS and has sucessfully trapped carbon and oxygen centred radicals with EPR spectra obtained. |
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |