ORGN 198 |
| Phosphate ions and their derivatives play important roles in signal transduction and energy storage in biological systems. For example, pyrophosphate can be a biologically important target because it is the product of ATP hydrolysis under cellular conditions. The detection of PPi is also considered important in cancer research. Accordingly, detection and discrimination of PPi on the basis of fluorescence changes has been the main focus of many research groups. Accordingly, the detection of pyrophosphate and inorganic phosphate is very important. We synthesized two chemosensors bearing two Zn(II)-DPA effectively recognize pyrophosphate and inorganic phosphate among anions examines at physiological pH. Acridine derivative 1 displayed a fluorescent quenching effect with pyrophosphate; on the other hand, a large fluorescent enhancement was observed with inorganic phosphate in 100 % aqueous solution. Another example is a naphtaldiimide derivative which shows a highly selective fluorescent change for PPi espeically over ATP via a unique 2+2 excimer formation at pH 7.4. |
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |