ORGN 195 |
| Sensors based on fluorescent changes appear to be particularly attractive due to the simplicity and high detection limit of the fluorescence. Catecholamines, including dopamine, are involved in a number of biological processes, such as Parkinson's disease and hypertension. A Rhodamine B derivative bearing boronic acid moiety has been prepared and used as fluorescent chemosensor. In order to detect biologically important copper ion in cells and organisms, monobroronic acid-conjugated rhodamine and bisboronic acid-conjugated fluorescein probes were designed and synthesized. The monoboronic acid-conjugated rhodamine probe displays a highly selective fluorescent enhancement with Cu2+, among the various metal ions. In contrast, the fluorescence of the bisboronic acid-conjugated fluorescein probe is selectively quenched by Cu2+, probably by way of a PET mechanism. The practical use of the monoboronic acid-conjugated rhodamine probe was demonstrated by its application to the detection of copper ions in mammalian cells and organisms. |
|
Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |