MEDI 210 |
| Drug abuse is a major public health problem in the United States. A large body of evidence indicates that k opioid receptors (kORs) are involved in the abuse related effects of drugs subject to abuse and may offer a pharmacological target to treat drug abuse and its attendant pathology. kORs have also been implicated in the actions of Salvia divinorum, a hallucinogenic mint plant that is currently unscheduled and readily available to the public over the internet. The active component of S. divinorum, the neoclerodane diterpene salvinorin A, has been identified as a potent and selective kOR ligand. As part of our program to develop novel compounds to treat drug dependence, we have begun to investigate the structure-activity relationships of the salvinorin A at opioid receptors. Here, we report that structural modification of salvinorin A has resulted in the identification of novel neoclerodane diterpenes with opioid receptor affinity and activity. |
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Smissman Award Symposium
9:00 AM-12:30 PM, Monday, August 20, 2007 BCEC -- 210 B/C, Oral
Division of Medicinal Chemistry |