TOXI 2 |
| There is an emerging appreciation for the complexity of the chemistry of reactive oxygen and nitrogen species arising at sites of inflammation in humans. With implications for developing biomarkers, the chemical reactions associated with inflammation span the full range of oxidation, reduction, alkylation, nitrosation and halogenation, with the damage affecting proteins, lipids, nucleic acids and carbohydrates. This talk will focus on recent observations of both oxidative and nitrosative DNA, RNA and protein damage arising directly as a result of exposure to nitric oxide and other chemical mediators of chronic inflammation, as well as indirectly from electrophiles generated from reaction of these species with lipids, proteins and carbohydrates. Studies performed with isolated nucleic acids, proteins and lipids, as well as cells and tissues from animal models of inflammation, have yielded unexpected results that suggest the need to refocus biomarker development efforts. |
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DNA-based Biomarkers
9:00 AM-11:50 AM, Sunday, August 19, 2007 BCEC -- 258C, Oral
Division of Chemical Toxicology |