ORGN 165 |
| Fluorescent probes are used widely to study biological functions of lipids. Among the many known fluorophores, dipyrrometheneboron difluoride chelate (BODIPY) is a suitable fluorophore for replacing part of the hydrophobic chain of lipids. We synthesized cholesterol and FTY720 analogs containing an ω-azido group and used cuprous iodide catalyzed Huisgen 1,3-dipolar cycloaddition reaction with a terminal alkyne attached to a BODIPY fluorophore to form lipid-fluorophore conjugates with 1,2,3-triazole as the linker.
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |
