Kinetics of chloramine-B oxidation of methionine in acid medium

ORGN 157

Sujatha Kesani, S-Kesani@wiu.edu1, Kishore Cholkar1, K. S. Rangappa2, and Netkal M. Made Gowda, GN-Made@wiu.edu1. (1) Department of Chemistry, Western Illinois University, 1 University Circle, Macomb, IL 61455, (2) Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore, 570 006, India
One of the greatest challenges in oxidation research today is the determination of in vivo oxidative stresses. Methionine (Met) is a sulfur-containing essential neutral amino acid. We have investigated the kinetics of oxidation of Met by sodium N-chlorobenzenesulfonamide (CAB) in perchloric acid solutions. The oxidation of Met by CAB in HClO4 has been spectrophotometrically monitored at ëmax = 245 nm. The reaction shows a first-order dependence of the rate on [CAB] and zero-order dependence on [Met] and [HClO4]. Variations of the ionic strength and the dielectric constant of the reaction medium have negligible effect on the rate. Based on the effect of temperature, activation parameters are evaluated. A mechanism consistent with the observed kinetic and activation data will be proposed. Acknowledgement: The authors thank the National Institute of Health (NIH-AREA grant # 5-20860) for support.
 

Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007