ORGN 146 |
| Electrophilic nucleosides are an important class of reagents since they can be converted to other nucleoside analogues by reaction with nucleophiles. We have developed a new class of O6-(benzotriazol-1-yl)inosine derivatives that are versatile electrophilic nucleosides. These compounds are easily prepared in high yields. The mechanism of their formation has been studied by 31P{1H} NMR. A DNA building block has also been prepared and a preliminary evaluation of its use for DNA modification has been performed.
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |
