6-Azidopurine nucleoside derivatives: Synthesis and NMR studies

ORGN 145

Manish K Singh, msingh@gc.cuny.edu and Mahesh K. Lakshman, lakshman@sci.ccny.cuny.edu. Department of Chemistry, The City College and The City University of New York, 138th Street at Convent Avenue, New York, NY 10031
The synthesis of 6-azido nucleosides has been of importance for the improvement of pharmacokinetic properties of drug candidates. In addition, the reactive nature of the azide moiety renders azido nucleosides of interest for cross-linking reactions with other cellular systems. For these reasons we have been interested in developing simple syntheses of C-6 azidopurine nucleoside analogues. We describe herein convenient syntheses of these compounds as well as an evaluation of these compounds by NMR.

 

Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007