CARB 32 |
| The non-translated region of hepatitis C virus (HCV) RNA contains an internal ribosome entry site (IRES) that is required for viral protein synthesis. We have used X-ray crystallography, fluorescent labelling in solution as well as binding studies with small-molecule ligands to investigate a highly conserved RNA motif in the HCV IRES which is a potential target for antiviral drug therapy. |
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Nucleic Acids as Drug Targets
1:40 PM-4:50 PM, Monday, August 20, 2007 BCEC -- 208, Oral
Division of Carbohydrate Chemistry |