Development of a practical synthesis of a potent, orally bioavailable calcitonin gene-related peptide (CGRP) receptor antagonist for the treatment of migraine

ORGN 14

Dietrich Steinhuebel1, Anthony Alorati2, Michael Ashwood2, Jenny Baxter1, Kevin Belyk, kevin_belyk@merck.com1, Brian Bishop2, Khateeta Emerson2, Ian W. Davies1, Andrew W. Gibson2, Michael Palucki1, Shane Krska1, and Yongkui Sun1. (1) Department of Process Research, Merck & Co, Rahway, NJ 07065, (2) Department of Process Research, Merck, Sharp & Dohme, Hertford Road, Hoddesdon, Hertfordshire, England
The talk will focus on the practical synthesis of the two key fragments of the drug candidate: trans-caprolactam and diamino-pyridine.

 

Combinatorial, Parallel, and Process Chemistry
8:00 AM-11:40 AM, Sunday, August 19, 2007 BCEC -- 253 A/B/C, Oral

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007