COLL 63 |
| Multilayered polymer thin films were constructed with a unique water-hydrolyzable polycation, allowing for the encapsulations and subsequent sequential releases of multiple drugs, with controls over the dosage and release kinetics of each encapsulated agent. We focus on the development of a coating for sequential delivery of pain killers with anti-inflammatories, antibiotics, and growth factors to be applied onto orthopedic implant surfaces. We have incorporated small-molecule antibiotics into these films without the need for any pre-modification, and demonstrated controls over encapsulation dosage and subsequent release rate through a variety of tuning factors. Several classes of antibiotics are under investigation, some with sustained release over one to two weeks, an ideal duration for infection control over biomedical implant surfaces. Aside from antimicrobial coatings, our findings can also be applied towards the coating-based delivery of other therapeutic agents, including proteins and nucleic acids, as well as other active ingredients in the non-medical industries. |
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Nanomaterials and Biological Applications: Diagnostic, Imaging, Biosensing and Drug Delivery
2:00 PM-5:15 PM, Sunday, August 19, 2007 BCEC -- 153C, Oral
Division of Colloid & Surface Chemistry |