INOR 29 |
| While extensive research has been conducted into citrate transport across biological membranes, there has been a relative dearth of investigation of membrane protein systems that can transport complexed, metal-bound, citrate. Given the importance of citrates in cellular respiration and the unknown fate of the metal ions accumulated, this represents a gap in our knowledge of a fundamental inorganic process. This is of particular significance with regard to microorganisms that have evolved to cover niches such as that of soil. Growth in such environments has demanded that these organisms develop ways of obtaining citrate bound to metals since citrate is a potent ligand for metal ions and thus free citrate is often unavailable. The biochemical mechanisms underlying this fundamental process are poorly characterized and efforts have focused on citrate bound to Mg, Ni, Co, Mn, Zn, and Ba and the uptake of these complexes by Streptomyces coelicolor A3(2), a ubiquitous soil based organism. |
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Bioinorganic Chemistry: Enzymes and Coenzymes
8:30 AM-12:10 PM, Sunday, August 19, 2007 BCEC -- 208, Oral
Division of Inorganic Chemistry |