Protein engineering, a versatile technique in materials science

PMSE 110

Jan C. M. van Hest, j.vanhest@science.ru.nl, Department of Organic Chemistry, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, Netherlands
In search for more complex and better defined materials, scientists have taken an increased interest in biomacromolecules such as proteins. Due to the templated polypeptide synthesis at the ribosomal production sites, nature has absolute control over protein molecular weight and primary amino acid sequence. The information that is stored in the linear polypeptide chain is translated via a folding process into well-defined threedimensional architectures, with specific structure and functionality. Compared to synthetic methodologies available for the polymer chemist, this natural way of polymer synthesis is still unsurpassed in its control. It has therefore been a logical step for materials scientists to adopt these biosynthetic procedures for the construction of -protein-based- materials. Protein engineering is nowadays regarded as a useful extension of the materials scientist's toolbox. In this paper different approaches will be described how the use of protein engineering can lead to smart molecular materials.
 

Polypeptide and Protein Materials
8:00 AM-11:40 AM, Monday, August 20, 2007 Westin Boston Waterfront -- Commonwealth Blrm C, Oral

Division of Polymeric Materials: Science & Engineering

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007