ORGN 677 |
4-Oxospiro[benzopyran-2,4'-piperidines] 1 are very useful scaffolds in drug discovery. This core structure is found in class III antiarrhythmics, alpha 1A-adrenergic receptor antagonists, 5-HT2A receptor antagonists and delta opioid receptor agonists. The synthesis of 4-oxospiro[benzopyran-2,4'-piperidines] 1 is well documented in the literature. There is no general method reported to prepare the tricyclic spirotetralones 2 (n = 1), congeners of 1 with isosteric replacement of the ring oxygen with a methylene group. We report a general and efficient synthetic approach to the novel tricyclic spiroketones with the general structure 2.
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Biologically-Related Molecules and Processes
8:00 AM-12:00 PM, Wednesday, August 22, 2007 BCEC -- 258B, Oral
Division of Organic Chemistry |