CHED 267 |
| The overexpression of the cytokine tumor necrosis factor-α (TNFα), has been linked to inflammation in Crohn's disease and has proven to be a viable therapeutic target. Our work focuses on the rational design and synthesis of small-molecule mimetics of the TNF receptor (TNFR). Using in silico modeling, we have designed a guanine-based scaffold that mimics the residues of TNFR involved in binding to TNFα. The synthesis and activity of these small molecule mimetics will be presented. |
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Undergraduate Research Poster Session
2:30 PM-4:30 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Chemical Education |