ANYL 305 |
| Live cell imaging has provided a wealth of information about cellular mechanisms and pathways of disease processes. The recent advancement in nanoparticles and green fluorescence protein (GFP) have greatly augmented biomedical optical imaging because nanoparticles offer ultrabrightness and tunable colors while GFP can be conjugated with the target protein and produced in vivo. We report here that nanoparticles consist of an organic photoisomerizable dye—spiropyran—as an optically responsive component and another fluorescent dye—perylene diimide—as a high-energy emitter. These dual color fluorescent nanoparticles were developed as potential new tools for biomedical applications and live cell imaging. When delivered into HEK-293 cells, they display either red or green fluorescence depending upon the wavelength of light to which the cells are highlighted. |
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Nano-Biochemistry and Technology
1:30 PM-5:00 PM, Monday, August 20, 2007 BCEC -- 104B, Oral
Division of Analytical Chemistry |