CHED 321 |
| PPAR δ, a ligand activated transcription factor, is of significant interest since little is known about its role in biological phenomena. Developing a focused library of small molecules with high binding affinity for PPAR δ will facilitate the exploration of this protein's function. Previously, a structural homology study and a computer-based docking study were performed to identify the unique characteristics of PPAR δ and to design organic compounds to potentially interact with these characteristics. A synthetic route using solid-phase methodology has been developed to reach the target library of small molecules. The library revolves around a proline functionalized resin and is diversified through the coupling of a variety of phenoxy-carboxylic acids and subsequent aryl-alkyl ether formation. Subsequent cleavage of the resin reveals a free carboxylic acid which can undergo amide formation to complete the synthesis of library members.
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Undergraduate Research Poster Session
2:30 PM-4:30 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Chemical Education |
