ORGN 5 |
| Hydrogen peroxide is major reactive oxygen species (ROS) in all living cells and is particularly abundant in the brain. Once viewed solely as a marker for oxidative stress resulting from imbalance of cellular redox chemistry, mounting evidence also points to the emerging concept of hydrogen peroxide as a second messenger in cellular signal transduction. Motivated to understand the complex physiological and pathological functions of peroxide biology at a cellular level, we are developing new chemical tools to map its cellular production, accumulation, trafficking, and function, with special interest in brain systems. This presentation will describe our most recent smart chemical probes for peroxide imaging and their application to living cells and tissue. |
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Young Academic Investigators
8:00 AM-12:00 PM, Sunday, August 19, 2007 BCEC -- Ballroom, Oral
Division of Organic Chemistry |