ORGN 536 |
| Beta-amino esters are biologically active molecules of great practical importance. They have been shown to have applications in numerous structural biology studies, and peptides composed of beta-amino esters have shown promise as therapeutics. The synthesis of these molecules is being investigated using an environmentally benign, one-pot approach. This reaction involves the indium-mediated reduction of nitroarenes to generate an amiline. The aniline is subsequently converted into an imine by addition of aldehyde, which is converted into product by addition of silyl ketene acetal. One unique aspect of these reactions is that the nitroarene reduction generates indium trichloride as a byproduct, which then catalyzes the subsequent reactions. |
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Physical Organic Chemistry, Metal-Mediated Reactions, Asymmetric Reactions and Syntheses
8:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |