ORGN 293 |
| Organometallic reagents are among the most powerful tools for C-C bond formation in the arena of organic synthesis. In light of the development of new or improved synthetic methodologies for C-C bond formation, reactions that involve the development of new organometallic reagents are always of great interest. In particular, other than the Grignard reagent, little information regarding the reactivity of other organometallic compounds of group II reagents exist. Thus, organometallic compounds of heavier alkaline-earth metals have not been pursued since little is known about their advantages over Grignard reagents. In our laboratories, R-Ba-X analogs of classic Grignard reagents with the expectation of the novel construction of C-C bond formation via a new methodology which may circumvent limitations associated with the use of R-Mg-X reagents are underway. In addition, mechanistic investigations of these organobarium reactions will be discussed. Moreover, synthetic applications of this protocol toward the preparation of biologically important target molecules will be presented.
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Metal-Mediated Reactions and Syntheses
8:00 AM-12:00 PM, Monday, August 20, 2007 BCEC -- 254 A/B, Oral
Division of Organic Chemistry |
