COLL 65 |
| The intravenous delivery of halogenated volatile anesthetics has been previously attempted using phospholipid-stabilized emulsions, such as Intralipid. However, fluorinated volatile anesthetics like sevoflurane are partially fluorophilic and do not mix well with classic non-fluorinated lipids. This effect limits the maximum amount of sevoflurane that can be stably emulsified in Intralipid to a mere 3.5% v/v, a considerable limitation to potential clinical use. We were able to prepare a 25% v/v sevoflurane emulsion using novel fluorinated surfactants, a significant increase compared to Intralipid. These emulsions are stabilized against coalescence, but susceptible to moderate Ostwald ripening due to the water solubility of sevoflurane (6mM). We will present a complete physical characterization of the emulsions as well as results of in vivo studies. |
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Nanomaterials and Biological Applications: Diagnostic, Imaging, Biosensing and Drug Delivery
2:00 PM-5:15 PM, Sunday, August 19, 2007 BCEC -- 153C, Oral
Division of Colloid & Surface Chemistry |