BIOT 431 |
| Self-assembled proteins hold tremendous promise for creating a range of useful nanoscaled templates. Advantages of protein templates include processing in aqueous environments and functionalization through standard genetic engineering to incorporate new chemistries, to embed enzymes, or to incorporate nucleating peptides for a diverse range of inorganic materials. In this talk, we describe the creation of specifically interacting proteins for ordered architectures through the application of powerful genetic selection technology. These architectures are based on the quaternary structure of a new type of filament protein (the γ prefoldin, or γ-PFD) from the hyperthermophile Methanocaldococcus jannaschii that we have previously discovered and characterized. These engineered filaments are to be used as building blocks for 3-D architectures of arbitrary geometry, and progress towards this end will be discussed. |
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Biophysical and Biomolecular Symposium: Protein Engineering
8:00 AM-11:00 AM, Thursday, August 23, 2007 BCEC -- 108, Oral
Division of Biochemical Technology |