BIOT 250 |
| This poster describes how industrial fluid mixing techniques, pilot-scale experiments and computational fluid dynamics (CFD) can be combined to insure optimal bioreactor scale-up and scale-down. The author will review industrial fluid mixing practice applied to bioreactor design along key validations for the use of CFD in modeling stirred tank reactors such as blend time, velocity fields and impeller power numbers. Turbulent energy dissipation rate will be discussed as an appropriate scale-up parameter for ensuring adequate mass transfer in bioreactors. The author will show how CFD can be used as a complementary tool with accepted industrial fluid mixing practice in the following areas: mixing equipment design outside standard mixing correlations, solid-liquid mixing, gas-liquid mixing, liquid-liquid mixing, probability statistics for turbulent energy dissipation and strain rate. The author offers his perspective on how CFD techniques can be used to complement the classic scale-up methods of industrial fluid mixing based on his experience and that of his colleagues while working for Cray Research, DuPont and Fluent. |
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Poster Session
5:30 PM-7:30 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Biochemical Technology |