BIOT 253 |
| Recent advances in the understanding of polyketide enzyme complexes have enabled the rational design and synthesis of novel polyketide molecules. This will soon enable a targeted approach to increase the titres of polyketides both novel and existing. The publication of genome sequences from filamentous actinomycetes has shown that these strains contain a vast potential for production of secondary metabolites. This represents a potential that is mainly unexplored and so far attempts to tap into this potential have been met with limited success. Generic rules for tapping this potential will be needed for rapid exploration/exploitation of these novel compounds. Modification of transcriptional regulators is an obvious option. This study describes the effect of targeted deletions in both global and pathway specific regulators in Saccharopolyspora erythraea. Five deletions strains were constructed which contained a deletion in each of 3 global regulators and 2 pathway specific regulators in Saccharopolyspora erythraea. |
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Poster Session
5:30 PM-7:30 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Biochemical Technology |