ORGN 876 |
| Plankortethers constitute a class of cytotoxic natural products, whose skeletons possess a highly substituted tetrahydrofuran ring. Synthetic approaches to this natural product family will require the ability to rapidly assemble the tetrahydrofuran with efficient diastereocontrol. Stereoselective assembly of substituted tetrahydrofuran systems can be accomplished through a two-step sequence involving a tandem chain extension-aldol reaction, followed by a Lewis acid mediated allylative cyclization.
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Combinatorial, Parallel and Process Chemistry, Heterocycles, Aromatics, New Reactions and Methodology
8:00 PM-10:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Organic Chemistry |
