Chiral SFC and HPLC to support “high throughput” process research

ANYL 408

Adam M Beard, adam_beard@merck.com, Xiaoyi Gong, Mirlinda Biba, Wes Schafer, Peter Sajonz, William R Leonard Jr., Derek W Henderson, and Christopher J Welch. Process Research, Merck & Co., Inc, RY801-C101, P.O. Box 2000, Rahway, NJ 07065
The increasing pace of drug discovery in recent years has brought about a faster pace in pharmaceutical process research. Supercritical fluid chromatography (SFC) and HPLC can be used to quickly develop chiral and achiral analytical methods to support ‘high throughput' process research. The analytical methods can then be easily translated to semi-preparative or preparative methods for the large scale purification of pharmaceutical intermediates. In this presentation we describe how SFC and HPLC can be used for rapid method development and analysis as well as for purification of pharmaceutical intermediates and active pharmaceutical ingredients (APIs) from milligram to kilogram scale.