Studies toward the total synthesis of a novel γ-lactone

CHED 323

Jessica Smith, William T. Spencer III, wts9594@rit.edu, Moni Agusto, and Christina G. Collison, cgcsch@rit.edu. Department of Chemistry, Rochester Institute of Technology, 85 Lomb Memorial Dr, Rochester, NY 14623
The novel γ-lactone, 1, was recently isolated from the Red Sea soft coral S. trocheliophorum that has been shown to inhibit the growth of certain bacteria. Our efforts are focused on using palladium coupling methods to facilitate a convergent construction of the lactone with the unsaturated side chain. The nonpolar side chain will be constructed through the use of a Stille mono-coupling using the highly sensitive 1,1-vinylidene dibromide.

 

Undergraduate Research Poster Session
2:30 PM-4:30 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Chemical Education

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007