INOR 184 |
| Leishmaniasis is the second most important tropical disease after malaria, affecting 12 million people and threatening 350 millions in 88 different countries around the world. The current treatment for this illness is based on pentavalent antimonial compounds, but they are toxic, produce severe side effects, and are not as effective against the most fatal form of the disease known as visceral Leishmaniasis. In the search for new potential chemotherapeutic drugs, metal-polypyridyl ligand complexes provide alternatives for this important health problem. Now, we are presenting the synthesis of [Cu(Ph3P)2dpq]NO3 (1), [Cu(Ph3P)2dppz]NO3 (2), [Cu(Ph3P)2dppa]NO3 (3) which were synthesized by the reaction of [Cu(Ph3P)2]NO3 with each ligand at mild condition. These complexes were characterized by elemental analysis, FAB-MS, NMR, UV-vis, and IR spectroscopies. DNA-copper-complex interactions were studied by spectroscopic and fluorescence titrations, electrophoretical assays and viscosity measurements. Our studies showed that these complexes interact with DNA. These observations, led us to carry out biological tests on cultures of promastigotes of Leishmania (L) mexicana and inhibition of the parasite growth was found.
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Bioinorganic Chemistry: DNA and RNA
7:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Inorganic Chemistry |