ORGN 545 |
| (Z)-1-Trimethylgermyl-1-alkenes easily prepared by the hydrozirconation of the corresponding 1-trimethylgermyl-1-alkynes followed by hydrolysis readily react with boron trichloride in hexanes for 4 h at room temperature. They resulting boron intermediates are then treated with water at 0 oC followed by extraction with ether. The resulting (Z)-1-alkenylboronic acids are then esterified with 1,3-propane diol in n-pentane for 1 h at room temperature. (Z)-1-Alkenylboronate esters are then isolated in good yieids (74%-88%) and their structures are confirmed by spectral (PMR and CMR) data. |
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Physical Organic Chemistry, Metal-Mediated Reactions, Asymmetric Reactions and Syntheses
8:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |