Production of D-lactic acid by the RITE bioprocess using genetically engineered Corynebacterium glutamicum

BIOT 282

Shohei Okino1, Masako Suda1, Masayuki Inui, inui@rite.or.jp1, Hideaki Yukawa, mmg-lab@rite.or.jp1, and Yoshiki Tsuchida2. (1) Microbiology Research Group, Research Institute of Innovative Technology for the Earth (RITE), 9-2 Kizugawadai, Kizu-shi, Kyoto, 619-0292, Japan, (2) Honda R&D Co., Ltd, 1-4-1 Chuo, Wako-shi, Saitama, 351-0193, Japan
The biodegradable polymer PLLA (poly L-lactic acid) can be produced from renewable resources. Its use, limited by its low heat stability, can be enhanced by blending with D-lactic acid derived PDLA (poly D-lactic acid). D-lactic acid production bioprocess need therefore be established for better utilization of PLLA. The Corynebacterium glutamicum-dependent RITE bioprocess has been demonstrated to achieve high volumetric productivities of various organic compounds under growth-arrested conditions. In this study, a genetically engineered C. glutamicum producing D-lactic acid was constructed, for RITE bioprocess application for D-lactic production. This study was partially supported by a grant from New Energy and Industrial Technology Development Organization (NEDO).
 

Poster Session
5:30 PM-7:30 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Biochemical Technology

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007