CINF 80 |
| Quantitative phosphoproteomics analysis is becoming a hotspot and provides the possibilities to study the dynamics of protein phosphorylation and to better understand the regulatory networks of key processes in cells. In this paper we present a quantitative application, which predicts the isoelectric points for peptides with and without methyl esterification. Numerical simulation of this model shows that methylated phosphopeptides and non-phosphopeptides can be grouped on the basis of the number of phosphate groups and basic residues in each peptide. The theoretical results are supported by experiments. We developed a SOAP webservice component and an Excel add-in and it can be easily integrated into Spotfire™ DecisionSite and SciTegic™ Pipeline Pilot. |
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General Papers
8:30 AM-11:50 AM, Thursday, August 23, 2007 BCEC -- 252 A, Oral
Sci-Mix
Division of Chemical Information |