ORGN 15 |
| An efficient and reliable three-step synthesis of 7-amino-3-hydroxyindan-1-one (1) is described. Compound 1 is now an accessible, three-dimensional, three-point scaffold and will be useful for the construction of focused compound libraries. Although indanone 1 has been mentioned in the literature, its preparation has not been recorded and the reported synthesis of its precursor is an experimental procedure that we could not repeat as described. In addition to the synthesis of indanone 1, we describe the preparation of a small set of derivatives that were prepared by functionalization of the amino group, which provides a pilot study for the preparation of a larger library of compounds that will be prepared using semi-automated parallel synthetic methods.
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Combinatorial, Parallel, and Process Chemistry
8:00 AM-11:40 AM, Sunday, August 19, 2007 BCEC -- 253 A/B/C, Oral
Division of Organic Chemistry |
