BIOT 279 |
| The culture environment is a highly critical factor to maximize cell growth and product titer. Over the last years product quality and the ability to modulate it was of high interest to Amgen. We could demonstrate that various culture methods, process setpoints and some nutrient concentrations can have a profound effect on the oligosaccharide structures of glycoproteins. This presentation will discuss how the percentage of high mannose species of an antibody can be significantly reduced, even modulated utilizing medium optimization strategies without compromising the overall product titer. |
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Poster Session
5:30 PM-7:30 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Biochemical Technology |