Electrochemical studies of some furyl, indole and phenyl derived sulfonamides with antimicrobial activities

ANYL 130

Raja S Machana, rsmachana@ualr.edu1, Zahid H Chohan, zchohan@mul.paknet.com.pk2, James Luba, jpluba@ualr.edu1, and Ali U. Shaikh, aushaikh@ualr.edu1. (1) Department of Chemistry, University of Arkansas at Little Rock, 2801 S. University Ave., Little Rock, AR 72204, (2) Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan
Sulfonamides are antimetabolites that find current therapeutic applications in the treatment of urinary tract infections, narcodiosis, and toxoplasmosis. Rapid development of bacterial resistance to this class of antimicrobials has obligated the need for synthesis of new sulfonamide derivatives. Electrochemical properties are one of the important attributes that determine the antimicrobial activity of drugs.

We have recently synthesized furyl, indol and phenyl derived sulphonamide. We employed cyclic voltametric and spectro-electrochemical techniques to study the electrochemical behavior of these compounds. We have also performed microbiological activity studies using Escherichia coli, Bacillus subtilis and Staphylococcal strains. Our data showed good correlation between the electrochemical properties and microbiological activity.

 

General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Analytical Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007