ANYL 82 |
| Sulfonamide drugs discovered in the 1930's were the first effective chemotherapeutic agents to be employed for the prevention and cure of bacterial infections in humans. Bacterial resistance to these drugs over the years have led to the development of new variety of sulfonamide derivatives. Recently we have synthesized a series of coumarin derived sulfonamides and their chemical structures have been established. In this report, we present some microbiological studies to establish the antibacterial characters of these compounds. In order to establish their chemical structure-biological activity relationship, in terms of oxidation-reduction characteristics, we have conducted cyclic volatmmetric studies of these compounds. Most of the compounds exhibit reduction peak potentials in the range of –960mV to –2300mV vs Ag/AgCl electrode. Spectroelectrochemical studies are being conducted to establish the mechanism of oxidation-reduction of these compounds. |
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General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Analytical Chemistry |