ORGN 17 |
| Melanin-concentrating hormone (MCH) is a 19-amino acid cyclic peptide known to play a role in feeding behaviour. Design of an antagonist for the MCH receptor could provide a drug to control over-eating. The MCHr1 antagonist 1 has been identified as a potential candidate for the treatment of obesity. A synthesis suitable for the large-scale preparation of 1 has been developed. Key features in the synthesis are the preparation of indole 2 via a Fisher indolization reaction and subsequent reductive amination with ester 3 or lactol 4 to afford the target compound. Route definition and optimization of studies will be presented.
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Combinatorial, Parallel, and Process Chemistry
8:00 AM-11:40 AM, Sunday, August 19, 2007 BCEC -- 253 A/B/C, Oral
Division of Organic Chemistry |
