COMP 88 |
| The creation of optical methods to analyze for enantiomeric excess during the high-throughput screening of asymmetric catalytic reactions is a current thrust of many academic and industrial laboratories. The approach presented at this poster session uses chiral synthetic receptors in arrays with simple indicators for signaling. The strategy is to use a core binding element that imparts a bias to each and every member of the array to a particular chiral functional group, ensuring affinity of the arrays members for a particular class of chrial analytes. Cross-reactivity among the receptors imparts the differential behavior desired in an array sensing application. The response of the array is used to train a pattern recognition algorithum, such as an artificial neural network. The arrays are then used to read the enantiomeric excess of truly unknown samples derived from synthetic chemistry procedures. |
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Bold Predictions in Theoretical Chemistry: A Poster Session in Honor of One of the Boldest, Bill Goddard, on the Occasion of his 70th Birthday
7:30 PM-9:30 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Computers in Chemistry |