CHED 40 |
| DNA-templated reactions are emerging as a general approach to control the reactivity of synthetic molecules by modulating the effective molarity. DNA templates align the reactive groups of these molecules to allow fast and selective reactions at reactant concentrations that are much lower than those required for conventional synthesis. A central issue in DNA-templated synthesis is the design of reactions using the DNA-template as catalyst. So far, approaches suffer from fast off template reactions or increased affinity of the product to the DNA-template, preventing high catalytic activity. Catalysis would support signal amplification and enable highly sensitive DNA-detection. We have developed a DNA-catalyzed transfer of a reporter group, generating high catalytic turnover numbers in a sequence-specific manner (Grossmann, T. N.; Seitz, O. J. Am. Chem. Soc. 2006, 128, 15596-15597). This DNA-catalyzed transfer is a new concept and is the first reaction to combine high catalytic activity of the DNA-template with useful reaction yields and low background. |
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Connections to Germany: Research and Education Opportunities
1:30 PM-5:00 PM, Sunday, August 19, 2007 Seaport -- Plaza A, Oral
Division of Chemical Education |