BIOT 40 |
| It is suggested here that properly designed counterflow cascades of permselective membranes can compete successfully with existing downstream processing techniques in a significant number of applications. They can produce much higher separation factors than the very simple configurations that still dominate membrane based separations. This claim will be supported using a combination of experimental data and process simulation. Effectiveness of HPTFF can be substantially increased by modifying individual modules and by incorporating them into an efficient counterflow cascade. Such cascades can be operated either batchwise or continuously. A primary practical problem of implementing such a process scheme in practice is solvent management, and strategies for dealing with this problem will be discussed. A major advantage of such a new technology is its relative insensitivity to diffusional limitations which become ever more stringent as we deal with larger molecules and even more complex moieties such as viruses, organelles and whole cells. |
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Downstream Processing: Primary Recovery - Membranes and Other Technologies
2:00 PM-4:15 PM, Sunday, August 19, 2007 BCEC -- 107 A/B, Oral
Division of Biochemical Technology |