Studies toward the total synthesis of a novel γ-lactone

ORGN 564

William T. Spencer III, wts9594@rit.edu, Jessica Smith, Moni Agusto, and Christina G. Collison, cgcsch@rit.edu. Department of Chemistry, Rochester Institute of Technology, 85 Lomb Memorial Dr, Rochester, NY 14623
A synthetic route toward a novel γ-lactone, 1, isolated from the Red Sea soft coral S. trocheliophorum is currently under investigation. The natural product has been shown to inhibit the growth of bacteria, namely Staphylococcus aureus and Bacillus subtilis. Our efforts are focused on using palladium coupling methods to facilitate a convergent construction of the lactone fragment with the unsaturated side chain.

 

Physical Organic Chemistry, Metal-Mediated Reactions, Asymmetric Reactions and Syntheses
8:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007