Nickel-catalyzed asymmetric cross-couplings of secondary allylic chlorides and alkylzinc reagents

ORGN 381

Sunghee Son, sunghee@mit.edu and Gregory C. Fu, gcf@mit.edu. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139
Asymmetric allylic substitution reactions using hard nucleophiles with functional group compatibility represent a useful addition to existing methods. Nickel-catalyzed Negishi cross-couplings of secondary allylic chlorides were developed expanding our highly enantioselective cross-coupling reactions. This method shows complementary scope and regioselectivity to other allylic substitution reactions.

 

Asymmetric Reactions and Syntheses
8:00 AM-12:00 PM, Tuesday, August 21, 2007 BCEC -- 253C, Oral

Division of Organic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007