The advent and develoment of organocatalysis

ORGN 427

David W. C. MacMillan, Department of Chemistry, Princeton University, 116 Frick Laboratory, Princeton, NJ 08540
“Organocatalysis: the field.” Over the last ten years, the field of organocatalysis has grown from a small collection of chemically unique or unusual reactions to a thriving area of general concepts, atypical reactivities and broadly useful reactions. While the modern era of organocatalysis still remains in its infancy, growth in this new chemical field continues to move at a breathtaking pace. In this presentation, we will demonstrate a variety of new and valuable transformations based on the paradigms of iminium-activation, enamine-activation, acid catalysis and SOMO catalysis. We will also highlight an alternative strategy for natural product synthesis that we hope will provide the strategic foundations to bypass the “taxol problem.”