Mimicking of iron-sulfur cluster proteins: Synthesis and electrochemical behavior of amphiphilic dendrimers

POLY 619

Anil Sharma, aksharm2@ncsu.edu, Deparment of Chemistry, North Carolina State University, Raleigh, NC 27695, Namjin Kim, Department of Chemistry, North Carolina State University, and Christopher Gorman, chris_gorman@ncsu.edu, Department of Chemistry, North Carolina State University, Box 8204, Raleigh, NC 27695-8204.
Abstract: Iron-sulfur cluster proteins are ubiquitous and evolutionary ancient prosthetic groups that are required to sustain fundamental life processes. Owing to their remarkable structural plasticity and versatile chemical/electronic features these proteins participate in electron transfer, substrate binding/activation, iron/sulfur storage, regulation of gene expression, and enzyme activity. We successfully synthesized first and second generation iron-sulfur cluster amphiphilic dendrimer in 7 and 9 steps respectively with high overall yield. The electrochemical behavior of these dendrimers was investigated using cyclic voltammetry. While G1 amphiphilic dendrimer showed quasi reversible behavior, G2 amphiphilic dendrimer was slower to reoxidize because of effective encapsulation of iron-sulfur cluster.
 

Metal-Containing and Metallo-Supramolecular Polymers and Materials
8:05 AM-12:00 PM, Thursday, August 23, 2007 Westin Boston Waterfront -- Stone, Oral

Division of Polymer Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007