ORGN 169 |
| More than 100 different natural nucleoside modifications are currently known. Most of them can be found in tRNA. Beside simple modifications like Inosine, Dihydrouridine or 1-Methyladenosine, more complex modifications like Archaeosine, Queuosine and Wybutosine exist. It is assumed that they interact with the ribosome in the translational process, but their exact function is not fully understood. The goals of our project are the total syntheses of these hypermodified nucleosides (and derivatives) and their incorporation into tRNA strands via automated solid phase synthesis. Functional studies of these nucleosides in tRNA, the translational process as well as their possible contribution to other biochemical processes will be investigated. We will present here a short, effective and modern synthesis of the natural, hypermodified nucleoside Queuosine as well as the synthesis of important key intermediates towards the synthesis of Wybutosine.
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Organic Chemistry |
