ORGN 696 |
| The structural simplicity of biaryl compounds belies their preparative complexity. Indeed, the search for efficient syntheses has captivated the attention of synthetic chemists for more than a century. Modern biaryl cross-coupling reactions based carbon fragment pre-activation, such as the Suzuki reaction, have revolutionized our ability to forge the carbon-carbon biaryl linkage. With the goal of reducing our dependence on pre-activation, attention is increasingly being focused on direct arylation processes which replace one of the pre-activated substrates with the simple arene itself. Important advances have been made, particularly in the past decade, and more can certainly be anticipated. In stark contrast, cross-coupling reactions that are completely devoid of arene pre-activation are rarely considered. This presentation will describe our recent work in the area of direct arylation as well as our efforts towards the development of a biaryl cross-coupling reaction that does not involve the pre-activation of either aromatic substrate. |
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Modern Organometallic Catalysis
1:00 PM-5:00 PM, Wednesday, August 22, 2007 BCEC -- 253 A/B/C, Oral
Division of Organic Chemistry |