Solid-Phase organic synthesis plays an important role in modern drug discovery.  This technique is widely used as a tool for development of target structure-activity-relationship (SAR) toward lead compounds for drug development.  However, utilization of solid-phase synthesis in obtaining small molecule isotopically labeled compounds has only been scarcely explored.  Hence, we sought to develop an efficient solid-phase synthetic strategy that would allow the preparation of carboxylic acids, particularly, those for which standard purification and isolation would be difficult due to lack of a UV chromophore.  We report herein a convenient method that takes advantage of the oxime resin as a solid support.  Two C-isotope labeled compounds were made by application of this technology.