Ability of dibutyltin polyamine derivatives of diaminopyrimidines to inhibit ovarian, bone, colon, lung, and breast cancer cells

PMSE 276

Kimberly Shahi, roner@uta.edu1, Michael R. Roner, roner@uta.edu1, Amitabh J. Battin, abattin@fau.edu2, and Charles E. Carraher Jr., carraher@fau.edu2. (1) Department of Biology, University of Texas at Arlington, Arlington, TX 76010, (2) Department of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431
Organotin polyamines were synthesized from reaction with a series of diaminopyrimidines of diorganotin dichlorides. The products are polymeric. The GI50 and CI50 values were obtained for 10 cell lines including cancer cell lines representing bone, prostrate, breast, colon, and lung cancers. The GI50 were in the same range and lower that the most widely used anticancer drug cisplatin. A number of CI values greater than 2 were found. There are some general correlations and other lack of correlations. For instance, activity appears to be independent of chain length. Presence of a thiol group is positive.
 

Joint PMSE/POLY Poster Session
6:00 PM-8:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Polymeric Materials: Science & Engineering

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007